As an advance in hydrofunctionalization, we herein report that alcohols add to 1,3-dienes with high regio- and enantioselectivity. Using Ni-DuPhos, we access enantioenriched allylic ethers. Through the choice of solvent-free conditions, we control the reversibility of C-O bond formation. This work showcases a rare example of methanol as a reagent in asymmetric synthesis.
CITATION STYLE
Li, Q., Wang, Z., Dong, V. M., & Yang, X. H. (2022). Enantioselective Hydroalkoxylation of 1,3-Dienes via Ni-Catalysis. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.2c12779
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