Fructose-Fed Induced Metabolic Syndrome Model in Cynomolgus Monkeys

Abstract

The incidences of obese and metabolic syndrome have risen dramatically in recent decades. The pathological conditions of metabolic syndrome greatly increase the risk factors of cardiovascular disease, type 2 diabetes and NASH. The over consumption of high-fructose in beverage has been considered may play a role in the causes. To better understand the association of excessive fructose intake and pathophysiological progressing for obesity, type 2 diabetes and NASH, we assessed anthropometrics and metabolic parameters in a total of 71 cynomolgus monkeys after the consumption of high fructose diet within a 12 months period, including but not limited to body weight, body fat, HbA1C, liver enzymes. All the assessment values showed as Mean ± SD, and have compared from baseline of pre-feeding of high fructose diet to the 12 months of post feeding. The result showed that about 13% monkeys were overt T2DM, 32% monkeys became obese with an impaired IVGTT profile and 31% monkeys obesity animals at last, many features of the metabolic syndrome such glucose and insulin impairment were existed in related cohorts. We demonstrated that dietary of high fructose induced metabolic syndrome in cynomolgus monkeys that provides a good translational animal model system to investigate obesity and metabolic syndrome pathogenesis, prevention and treatment.