Abstract
The most common alpha-1 antitrypsin (AAT) mutant variant is a missense mutation (E342K), commonly referred to as PiZ. A transgenic mouse model exists that expresses the mutant human PiZ AAT gene. This protocol outlines the procedure used to extract DNA from and genotype AAT transgenic (PiZ) mice.
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APA
Gruntman, A. M. (2017). Genotyping protocol for the alpha-1 antitrypsin (PiZ) mouse model. In Methods in Molecular Biology (Vol. 1639, pp. 61–65). Humana Press Inc. https://doi.org/10.1007/978-1-4939-7163-3_6
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