Parkinson’ s disease (PD) is associated with distinctive and highly localized pathologic changes in the brain. Degeneration of substantia nigra pars compacta neurons within the midbrain is pronounced in patients with PD. These dopaminergic neurons project to the striatum, and loss of striatal dopamine is responsible for most of the motor deficits of PD.
CITATION STYLE
LeWitt, P. A. (2000). Parkinson’s Disease: Etiologic Considerations. In Parkinson’s Disease and Movement Disorders (pp. 91–100). Humana Press. https://doi.org/10.1007/978-1-59259-410-8_6
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