Non-myeloablative allografting from human leucocyte antigen-identical sibling donors for treatment of acute myeloid leukaemia in first complete remission

90Citations
Citations of this article
18Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Many patients with acute myeloid leukaemia (AML) in first complete remission (CR1) are ineligible for allogeneic transplantation as a result of age or medical problems other than leukaemia. Eighteen patients (median age 59 years, range 36-73 years) with de novo (n = 13) and secondary (n = 5) AML in morphological CR1, who were not candidates for conventional allografting, received non-myeloablative peripheral blood stem cell transplants from human leucocyte antigen identical sibling donors after conditioning with 2 Gy total body irradiation (TBI; n = 10) or 2 Gy TBI and 90 mg/m2 of fludarabine (n = 8). Post-grafting immunosuppression was with cyclosporine and mycophenolate mofetil. Two rejections were observed in patients not given fludarabine and one died with relapse. Overall, 10 patients died between 77 and 841 d, seven from relapse and three from non-relapse mortality (NRM). Day +100 NRM was 0% with a 1-year estimated NRM of 17% [95% confidence interval (CI) 0-35%]. The median follow-up among the eight survivors was 766 d (range, 188-1141 d). Seven of these eight survivors remain in complete remission (CR). One-year estimates of overall and progression-free survivals were 54% (95% CI 31-78%) and 42% (95% CI 19-66%) respectively. While follow-up is short, this analysis demonstrates that the procedure is sufficiently safe to be studied in a wider group of patients.

References Powered by Scopus

World health organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: Report of the clinical advisory committee meeting - Airlie house, Virginia, November 1997

2557Citations
N/AReaders
Get full text

Graft-versus-leukemia reactions after bone marrow transplantation

2528Citations
N/AReaders
Get full text

The importance of diagnostic cytogenetics on outcome in AML: Analysis of 1,612 patients entered into the MRC AML 10 trial

2450Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Hematopoietic cell transplantation (HCT)-specific comorbidity index: A new tool for risk assessment before allogeneic HCT

2433Citations
N/AReaders
Get full text

Sequential regimen of chemotherapy, reduced-intensity conditioning for allogeneic stem-cell transplantation, and prophylactic donor lymphocyte transfusion in high-risk acute myeloid leukemia and myelodysplastic syndrome

361Citations
N/AReaders
Get full text

Morbidity and mortality with nonmyeloablative compared with myeloablative conditioning before hematopoietic cell transplantation from HLA-matched related donors

282Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Feinstein, L. C., Sandmaier, B. M., Hegenbart, U., McSweeney, P. A., Maloney, D. G., Gooley, T. A., … Storb, R. F. (2003). Non-myeloablative allografting from human leucocyte antigen-identical sibling donors for treatment of acute myeloid leukaemia in first complete remission. British Journal of Haematology, 120(2), 281–288. https://doi.org/10.1046/j.1365-2141.2003.04057.x

Readers over time

‘11‘12‘13‘14‘15‘16‘17‘18‘19‘20‘21‘2300.751.52.253

Readers' Seniority

Tooltip

Professor / Associate Prof. 6

50%

PhD / Post grad / Masters / Doc 6

50%

Readers' Discipline

Tooltip

Medicine and Dentistry 7

58%

Social Sciences 2

17%

Agricultural and Biological Sciences 2

17%

Pharmacology, Toxicology and Pharmaceut... 1

8%

Save time finding and organizing research with Mendeley

Sign up for free
0