6011Outcomes in patients treated with ticagrelor versus clopidogrel after acute myocardial infarction in relation to renal function: 1-year SWEDEHEART registry data

Abstract

Methods: Follow-up data in MI survivors from 1 Jan 2010 to 31 Dec 2013 discharged on ticagrelor or clopidogrel enrolled in the Swedish MI registry (SWEDEHEART) was evaluated. The association between ticagrelor versus clopidogrel and the composite outcome of death, MI, stroke, and bleeding (defined as re-hospitalizations with bleeding) at 1-year was studied using Cox proportional hazards models, adjusting for hospital, calendar time, baseline characteristics, in-hospital complications and treatments and other medications at discharge and stratifying for renal function (eGFR). To study in-hospital bleeds in patients undergoing percutaneous coronary intervention (PCI) (n=36,392), logistic regression analysis was used, adjusting for hospital, calendar time, baseline characteristics, antithrombotic treatment during PCI and vascular access.