Seronegative Spondyloarthropathies

Abstract

The seronegative spondyloarthropathies (SpAs) are a group of disorders including ankylosing spondylitis (AS), non-radiographic axial spondyloarthritis (nr-axSpA), psoriatic arthritis (PsA), inflammatory bowel disease (IBD)-associated arthritis, reactive arthritis, and juvenile-onset spondyloarthritis (JSpA). These disorders are termed seronegative due to the absence of rheumatoid factor (RF). While there is a great deal of clinical heterogeneity among these disorders, they share several characteristic musculoskeletal features including inflammatory back pain, asymmetric oligoarthritis, enthesitis, dactylitis, and an association with human leukocyte antigen (HLA)-B27 positivity.