We report the use of a biofunctionalized tapered optical fiber based sensor with the integration of graphene oxide (GO) for the detection of Dengue virus (DENV) II E proteins. The tapered region was deposited with GO and functionalized with anti-DENV II E protein IgG antibodies to be tested with different concentrations of DENV II E proteins. The sensor obtained a detection limit of 1 pM with a sensitivity value of 12.77 nm/nM, which was better compared to previously reported studies. The sensor also showed high precision, great selectivity, and high affinity toward E protein with a dissociation constant of Kd = 1.11 × 10-9 M-1. The proposed sensor has undoubtedly exhibited the immense potential of nanomaterial integration for future advancements of dengue diagnostics.
CITATION STYLE
Kamil, Y. M., Bakar, M. H. A., Yaacob, M. H., Syahir, A., Lim, H. N., & Mahdi, M. A. (2019). Dengue e Protein Detection Using a Graphene Oxide Integrated Tapered Optical Fiber Sensor. IEEE Journal of Selected Topics in Quantum Electronics, 25(1). https://doi.org/10.1109/JSTQE.2018.2846044
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