The Opiate Receptors

Abstract

In 1988, Gavril W. Pasternak published the first edition of this seminal text. It was a lucidaccount of the latest knowledge on opiate receptors and related receptor subtypes, athen controversial field, providing an integrated approach correlating the biochemical, physiological, and pharmacological aspects of opiate reaction.Fully revised and expanded, The Opiate Receptors, 2nd edition presents all the advancesmade in the field in the past twenty years. It covers a wide variety of topics including, but not limited to, the following: pharmacology of opioid drugs; endogenous opioids;molecular biology of mu receptors; molecular biology of delta receptors; kappa opioidreceptor gene and the regulatory mechanisms of its protein expression; opioid receptorsignal transduction mechanisms; mu opioid receptor mediated analgesia and reward;kappa opioid receptor function; delta opioid receptor function; genetics of opioid receptorfunctions in mice; opioid receptor trafficking; opioid receptor dimerization; molecularmodulation of in vivo tolerance; and genetics of opioid actions.Written by leading international researchers in the field, this new edition is as groundbreakingand vital as its predecessor.