Enantioselective organocatalytic reactions of 4-hydroxy-coumarin and 4-hydroxypyrone with α,β-unsaturated aldehydes - An efficient Michael addition-acetalization cascade to chromenones, quinolinones and pyranones

Abstract

An efficient, organocatalytic enantioselective addition-cyclization reaction of cyclic 1,3-dicarbonyl compounds with different α,β- unsaturated aldehydes has been developed. The diarylprolinol ether-catalyzed reaction cascade provides a variety of chromenones, quinolinones and pyranones in good yields and with excellent enantioselectivities. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.