Effect of Bioosteo®in combination with epidermal growth factor and ascorbic acid in a rat tibia defect

Abstract

Background: Treatment of bone defects derived from trauma or from removal of tumors or osteosynthesis materials can cause socioeconomic problems as a result of treatment length. objective: The purpose of this study was to determine the effect of the implant material BioOsteo®in combinations with epidermal growth factor (EGF) and ascorbic acid (AA) on the consolidation of a non-critical size bone defect. Materials and methods: A unicortical non-critical bone defect was practiced in the right tibia of Wistar rats and 3 weeks later, a biomechanical property analysis was performed through a three-point bending test. results: We found that a 1 time single-dose local application of AA + EGF + BioOsteo®directly over the non-critical bone defect microenvironment improves its repair.