Polysaccharides in Fungi. XXXII.1) Hypoglycemic Activity and Chemical Properties of a Polysaccharide from the Cultural Mycelium of Cordyceps sinensis

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Abstract

Crude polysaccharides were obtained from a hot-water extract and alkaline extracts of the cultural mycelium of Cordyceps sinensis. They showed significant activity in normal mice and streptozotocin-induced diabetic mice as a result of intraperitoneal (i.p.) injection. A crude polysaccharide (CS-OHEP) obtained from 5% sodium hydroxide extract slightly lowered the plasma glucose level in normal mice by oral (p.o.) administration. A neutral polysaccharide (CS-F30) exhibited higher hypoglycemic activity than its crude polysaccharide (CS-OHEP), exhibited by i.p. injection, and it significantly lowered the glucose level by p.o. administration (50 mg/kg). However, it hardly affected the plasma insulin level in normal mice. CS-F30 ([α]D+21°in water) is composed of galactose, glucose and mannose (molar percent, 62: 28: 10), and its molecular weight is about 45000. © 1993, The Pharmaceutical Society of Japan. All rights reserved.

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Kiho, T., Yamane, A., Ukai, S., & Hui, J. (1993). Polysaccharides in Fungi. XXXII.1) Hypoglycemic Activity and Chemical Properties of a Polysaccharide from the Cultural Mycelium of Cordyceps sinensis. Biological and Pharmaceutical Bulletin, 16(12), 1291–1293. https://doi.org/10.1248/bpb.16.1291

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