Detection and characterization of intracranial aneurysms with dual-energy subtraction CTA: Comparison with DSA

Abstract

Background: To investigate the diagnostic performance of dual-energy subtraction CTA in evaluating intracranial aneurysms by comparison with DSA. Methods: Ninety-seven patients with suspected intracranial aneurysms were included into our study and completed both 64-section dual-energy subtraction CTA and DSA examinations. Two independent readers retrospectively reviewed all subtraction CTA images in a blinded manner. Sensitivity, specificity, positive predictive value and negative predictive value of subtraction CTA and DSA were calculated on a per-patient and per-aneurysm basis. Results: According to the reference standard, 96 aneurysms were present in 81 patients and no aneurysm was found in 16 patients. The overall sensitivity, specificity, positive predictive value and negative predictive value of subtraction CTA on a per-aneurysm basis were 98.9, 100, 100 and 94.1%, respectively. DSA prospectively detected 88 aneurysms in 79 of 81 patients. On a per-aneurysm basis, the sensitivity, specificity, positive predictive value and negative predictive value of DSA were 91.7, 100, 100 and 66.7%, respectively. Conclusion: The diagnostic accuracy of 64-section dual-energy subtraction CTA is promising in detection and characterization of intracranial aneurysms. In most cases, it may substitute for conventional DSA as the primary imaging method in the diagnostic work-up of intracranial aneurysms. © Springer-Verlag/Wien 2011.