A systematic study of the stability of a set of cephalosporins in mouse plasma reveals that cephalosporins lacking an acidic moiety at C-2 may be vulnerable to β-lactam cleavage in mouse plasma.
CITATION STYLE
Zimmerman, M., McDonald, S. L., Ho-Liang, H. P., Porubsky, P., Nguyen, Q., Pharr, C. W., … Aubé, J. (2019). Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma. Journal of Antibiotics, 72(6), 469–475. https://doi.org/10.1038/s41429-019-0167-y
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