Cholesterol seco-sterol-induced aggregation of methylated amyloid-β peptides - Insights into aldehyde-initiated fibrillization of amyloid-β

Abstract

(Chemical Equation Presented) Hot spot on amyloid-β? Atheronal-B-induced aggregation of amyloid-β (Aβ) involves a site-specific adduction of the aldehyde to the ε-amino group of Lys 16, suggesting that Lys 16 is a hot spot for atheronal-induced fibrillization of Aβ (see scheme). This process can be inhibited by molecules like cholesterol that compete for the central hydrophobic cluster binding domain. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.