Anti inflammatory test of centella asiatica extract on cadmium induced rats

Abstract

Cadmium is a toxic heavy metal which pollute the environment parallel with human activities in such industries like textiles and weldings. The presence of cadmium in human body caused liver inflammation. This study was aimed to know the anti inflammatory effects of Centella asiatica extract on cadmium induced rats. This research used an experimental study applying a post test only control group design. Twenty four rats were devided into six groups with four replications, i.e group of healthy control (C1), negative control (CdSO4-induced rats) at the dosage of 56 mg/kgbw for 10 days. Meanwhile (C3-C6 treatments) had dosage of 100, 200, 300 and 400 mg/kgbw The blood Cd content, GST, GSH, TNF- α and COX-2 were measured following the administration of C. asiatica 14 days. and analyzed by ANOVA test. Statistical analysis will be continued by the Duncan test when there was a significance difference at 5%. The result showed that administration of C.asiatica extract was able to neutralize cadmium, as well as restoring the inflammatory level. The conclusion of this research that C. asiatica extract at dosage of 200 mg/kgbw was the most effective dosage to decrease Cd level, TNF-α and COX-2 levels but increase GST and GSH level.