Sensitivity of Aeromonas hydrophila carbapenemase to δ3-cephems: Comparative study with other metallo-β-lactamases

Abstract

Ceftriaxone and ceftriaxone S-oxide behaved as inactivators against the metallo-β-lactamase of Aeromonas hydrophila AE036 and as substrates for the zinc β-lactamase produced by Bacillus cereus (569/H/9) and Stenotrophomonas maltophilia ULA 511. Moreover, RO 09-1428, a catechol-cephalosporin, was not recognized by the A. hydrophila enzyme. Panipenem, cephalosporin C, cephalosporin C-γ-lactone, and loracarbef were substrates for the three studied β-lactamases.