The actin cytoskeleton and membrane organisation in T lymphocytes

Abstract

The dynamics of the actin cytoskeleton are under the strong influence of signalling events at the membrane and membrane domains. In T cells, the importance of actin-membrane-interactions is critical in the processes of T cell activation and migration. If the coordination of actin and the T lymphocyte membrane are out of order, it can compromise the human immune system and lead to immunodeficiencies.