Ubiquitylation-mediated fine-tuning of dna double-strand break repair

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Abstract

The proper function of DNA repair is indispensable for eukaryotic cells since accumulation of DNA damages leads to genome instability and is a major cause of oncogenesis. Ubiquitylation and deubiquitylation play a pivotal role in the precise regulation of DNA repair pathways by coordinating the recruitment and removal of repair proteins at the damaged site. Here, we summarize the most important post-translational modifications (PTMs) involved in DNA double-strand break repair. Although we highlight the most relevant PTMs, we focus principally on ubiquitylation-related processes since these are the most robust regulatory pathways among those of DNA repair.

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Borsos, B. N., Majoros, H., & Pankotai, T. (2020, June 1). Ubiquitylation-mediated fine-tuning of dna double-strand break repair. Cancers. MDPI AG. https://doi.org/10.3390/cancers12061617

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