The relationship between ABO groups and subgroups, factor VIII and von Willebrand factor

Abstract

The aim of this study was to correlate ABO groups with plasma levels of factor VIII (FVIII), von Willebrand factor (VWF:Ag), and ristocetin cofactor (VWF:RCo). Serological and molecular tests defined blood groups from 114 donors (10 AA, 10 BB, 10 AB, 10 AO1, 10 BO1,16 O 1O1, 20 A2O1, 20 A2B, 4 A3O1, 3 AxO1, and 1 B elO1). The levels of VWF:Ag, FVIII and VWF:RCo observed in rare subgroups (A3O1, AxO1, B elO1) were similar to the values found in the O 1O1 group. However, levels of these factors were significantly higher in A2O1 donors than in O 1O1 donors (VWF:Ag p=0.01; FVIII p=0.04; VWF:RCo p<0.001). Strong correlations were demonstrated between plasma levels of VWF:Ag and FVIII (R=0.77; p=0.001) and between VWF:Ag and VWF:RCo (R=0.75; p=0.001). ©2007 Ferrata Storti Foundation.