Global trend of clinical biomarkers of health and disease during the period (1913–2021): systematic review and bibliometric analysis

Abstract

Background: The literature review provides a concise and detailed description of the available and published data on the investigated research problem. The study summarizes findings over the last 100 years regarding clinical biomarkers during health and disease. Research expanded to present the range of enzyme acetylcholinesterase in human blood utilizing diverse methodology during the 1949–2021 year. Main body: Data analysis includes program SPSS v23.0, frequency, percentage, numbers and graphical presentation of results. Information from the papers gathers in Microsoft Excel 2007 and contains information: study type, journal, publisher, year of publication, continent, the health status of respondents, biomarkers, number and age of participants, types of samples, methodology, goals and conclusions. Data collection includes electronic databases, the National Center for Biotechnology Information and Google Scholar, with several inclusion criteria: (1) anthropometry (2) urine (3) blood in the healthy and diseased population parameters during different physiological states of the organism. The initial number of collected and analyzed papers is 1900. The final analysis included 982 studies out of 1454 selected papers. After the selection process, 67.53% remains useful. The range of enzyme acetylcholinesterase included 107 publications. Conclusion: The number of published scientific papers has been increasing over the years. Little practical information in scientific and clinical practice exists. There is an urgent need for concise highlighting of literature key arguments and ideas. Results apply to a specialized area of research.