Objective: to assess the effectiveness of 2% papain gel compared to 2% carboxymethyl cellulose in the treatment of chronic venous ulcer patients. Method: randomized controlled clinical trial with 12-week follow-up. The sample consisted of 18 volunteers and 28 venous ulcers. In the trial group, 2% papain gel was used and, in the control group, 2% carboxymethyl cellulose gel. Results: the trial group showed a significant reduction in the lesion area, especially between the fifth and twelfth week of treatment, with two healed ulcers and a considerable increase in the amount of epithelial tissue in the wound bed. Conclusion: 2% papain gel demonstrated greater effectiveness in the reduction of the lesion area, but was similar to 2% carboxymethyl cellulose gel regarding the reduction in the amount of exudate and devitalized tissue. Multicenter research is suggested to evidence the effectiveness of 2% papain gel in the healing of venous ulcers. UTN number: U1111-1157-2998.
CITATION STYLE
Rodrigues, A. L. S., de Oliveira, B. G. R. B., Futuro, D. O., & Secoli, S. R. (2015). Effectiveness of papain gel in venous ulcer treatment: Randomized clinical trial. Revista Latino-Americana de Enfermagem, 23(3), 458–465. https://doi.org/10.1590/0104-1169.0381.2576
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