Computer implementation of robust controllers for anesthesia

Abstract

The reversible state of a general anesthesia encompasses three components: hypnosis, paralysis and analgesia. In this paper design and implementation issues of the controllers used to maintain paralysis and hypnosis are presented. The controllers are designed from model databases of compartmental models and rely on the H∞ method. In order to cope with the variability of the patient models, robust techniques are used to produce a controller that is able to withstand robust stability and robust performance. The controllers are designed in continuous and discretized for computer implementation. Clinical results during elective surgery are presented to illustrate the results obtained. © 2015 Springer International Publishing.