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Antimetabolites: Antibiotics That Inhibit Nucleotide Synthesis

  • Bhattacharjee M
Springer International Publishing, (2016), 95-108
DOI: 10.1007/978-3-319-40746-3_4
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Abstract

Antimetabolites as antibiotics that inhibit the synthesis of nucleotides needed for nucleic acid synthesis. Background biochemistry on folic acid metabolism is included. Antibiotics presented are sulfa drugs, p-aminosalicylic acid, dapsone, trimethoprim, and fluorouracil. Methotrexate is discussed as an anticancer drug. Mechanisms of action of all these antibiotics are also discussed.

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APA

Bhattacharjee, M. K. (2016). Antimetabolites: Antibiotics That Inhibit Nucleotide Synthesis. In Chemistry of Antibiotics and Related Drugs (pp. 95–108). Springer International Publishing. https://doi.org/10.1007/978-3-319-40746-3_4

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