Anti-B7-H4

Abstract

B7-H4, also known as B7x or B7S1, is a new member of the B7 family of immune co-signaling molecules. Despite the wide distribution in mRNA levels, B7-H4 protein expression is generally absent in peripheral tissues but is increased on many cancer cells or tumor-associated immune cells. In addition, B7-H4 upregulation has shown to be associated with diseases progression and/or outcome in some cancers. The unique expression of B7-H4 in the tumor microenvironment and its potential immune inhibitory functions on both innate and adaptive immune responses represents a novel target for the next-generation cancer diagnosis and immunotherapy.