Adenocarcinoma, Prostate, Rat

Abstract

Some prostatic carcinomas are of microscopic size, but others are so large and embedded in other structures that it is difficult to determine from which accessory sex gland they originate. Grossly detectable carcinomas of the ventral prostate hscvQ been reported in aging ACI/ segHapBR rats (Ward et al. 1980). They are visible as hemorrhagic and pigmented nodular masses. Smaller, grossly visible carcinomas of the dorsolateral prostate are typically located at the base of the seminal vesicle/coagulating gland (Fig. 293). They can be symmetrically located in the middle of the dorsolateral prostate, sometimes surrounding the urethra, or they can be found on one side of this lobe. They are rather firm, multinodular tumors, with occasional central necrosis or hemorrhagic areas.