Metal ions modulate the conformation and stability of a G-quadruplex with or without a small-molecule ligand

21Citations
Citations of this article
27Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Small-molecule ligands for stabilizing the G-quadruplex in telomeres are promising chemotherapeutic agents. Despite extensive research, few G-quadruplex-stabilizing ligands have been clinically approved to date. We hypothesized that metal ions may be able to interfere with the ligand-mediated stabilization of the G-quadruplex. Here we found that several metal ions could interfere with the Na+-induced G-quadruplex conformation even in the presence of a ligand. The destabilizing effects of metal ions may not be negligible as most of them are essential elements in organisms. In contrast, Ba2+ was found to be a potent stabilizing cation, which could compete with other destabilizing cations to modulate the stability of the G-quadruplex. Moreover, the destabilizing effects of divalent or trivalent cations were considerably inhibited when a metal chelator was used. These data suggested that the unfavorable effects of destabilizing cations must be minimized for enhancing the ligand-mediated stabilization of the G-quadruplex.

Cite

CITATION STYLE

APA

Lu, H., Li, S., Chen, J., Xia, J., Zhang, J., Huang, Y., … Hu, Y. (2015). Metal ions modulate the conformation and stability of a G-quadruplex with or without a small-molecule ligand. Metallomics, 7(11), 1508–1514. https://doi.org/10.1039/c5mt00188a

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free