Association between matrix metalloproteinase-1 (Mmp-1) protein level and the risk of rheumatoid arthritis and osteoarthritis: A meta-analysis

Abstract

Recent publications have investigated the potential role of the protein level of matrix metalloproteinase-1 (MMP-1) in the susceptibility to rheumatoid arthritis (RA) and osteoarthritis (OA). However, no unanimous conclusion was obtained. Therefore, we carried out a meta-analysis to explore the association between MMP-1 expression and these two clinical disorders. After database searching and screening, we enrolled a total of eighteen articles for the pooled analysis. We observed a significant association between RA cases and controls in the whole population [SMD (standard mean difference)=1.01, P=0.017]. There were similar positive results in the subgroup analysis of ‘‘population-based control’’ (SMD=1.50, P=0.032) and ‘‘synovial fluid’’ (SMD=1.32, P=0.049). In addition, we observed an increased risk in OA cases, compared with controls, in the overall analysis (SMD=0.47, P=0.004) and subsequent subgroup analysis of ‘‘knee OA’’ (SMD=0.86, P<0.001), ‘‘Asian/China’’ (SMD=0.76, P=0.003), ‘‘cartilage-Asian/China’’ (SMD=1.21, P<0.001), and ‘‘synovial fluid-Asian/China’’ (SMD=0.73, P=0.004). In summary, a high protein level of MMP-1 in synovial fluid may be associated with the susceptibility to RA, and the high MMP-1 level in the cartilage tissue or synovial fluid may be related to the pathogenesis of knee OA in the Chinese population. This should be confirmed by larger sample sizes.