An enterotoxigenic Escherichia coli plasmid encoding colonization factor antigen (CFA) I fimbriae and heat-stable toxin was transferred into a streptomycin-resistant mutant of the Salmonella typhi galE strain Ty21a (a live attenuated oral typhoid vaccine). The virulence plasmid-carrying transconjugants produced CFA I fimbriae and heat-stable toxin. The marked production of CFA I fimbriae was observed even in a vaccine medium for Ty21a. The data lead to a new type of potential live oral vaccine, S. typhi Ty21a producing enteroadhesion fimbriae.
CITATION STYLE
Yamamoto, T., Tamura, Y., & Yokota, T. (1985). Enteroadhesion fimbriae and enterotoxin of Escherichia coli: Genetic transfer to a streptomycin-resistant mutant of the galE oral-route live-vaccine Salmonella typhi Ty21a. Infection and Immunity, 50(3), 925–928. https://doi.org/10.1128/iai.50.3.925-928.1985
Mendeley helps you to discover research relevant for your work.