A growing appreciation of NADPH oxidases (NOXs) as mediators of fundamental physiological processes and as important players in myriad diseases has led many laboratories on a search for specific inhibitors to help dissect the role in a given pathway or pathological condition. To date, there are only a few available inhibitors with a demonstrated specificity for a given isozyme. Among those, peptidic inhibitors have the advantage of being designed to target very specific protein-protein interactions that are essential for NOX activity. Herein, we provide the techniques to deliver these inhibitors both in cell culture as well as in vivo.
CITATION STYLE
Cifuentes-Pagano, E., & Pagano, P. J. (2019). Rational design and delivery of NOX-inhibitory peptides. In Methods in Molecular Biology (Vol. 1982, pp. 417–428). Humana Press Inc. https://doi.org/10.1007/978-1-4939-9424-3_24
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