KINETIC SOLUBILITY OF FISETIN NANOCRYSTAL

Abstract

Background: Fisetin (3,3,4,7-tetrahydroxyflavone) is a natural antioxidanthaspoor solubility leads to poorbioavailability and limits its development. Fisetinnanocrystals were produced by nanoprecipitation technique and transformed into dry powder by lyophilisation. Objective: The aim of the study is to investigate the kinetic solubility of fisetinafter produced into nanocrystals. Methods: Fisetin nanocrystalswere prepared by nanoprecipitationwith different proportion of stabilizers and transformed into dry powder by lyophilization. In a period of 1 week, the kinetic solubility was determined using a shaker water bath at 37OC. Result: Showed fisetin nanocrystals were almost completely dissolved within 15 min in water and buffer pH 1,2. In contras, only 55% of fisetin raw material at the same condition. Conlusions: Lyophilizedfisetinnanocrystals could be re-dispersed completely in water, buffer pH 1,2 and the kinetic solubility in water increased to 420 ηg/ml.