Abstract
The development of new antibiotics effective against all strains of tuberculosis (TB) is needed. To evaluate the potential of marine microbe-derived natural products as anti-TB leads, we analyzed and compared the physico-chemical properties of 39 current TB drugs and candidates against 60 confirmed mycobacteria-active natural products. We showed that anti-TB natural products sourced from marine microbes have a large overlap with TB drug-like space. A model to predict potential anti-TB drugs is proposed.
Cite
CITATION STYLE
Liu, M., Grkovic, T., Zhang, L., Liu, X., & Quinn, R. J. (2016, August 1). A model to predict anti-tuberculosis activity: Value proposition for marine microorganisms. Journal of Antibiotics. Nature Publishing Group. https://doi.org/10.1038/ja.2016.87
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