We report an open-label study comparing tadalafil and acetazolamide (n = 24) versus acetazolamide (n = 27) for prevention of high-altitude illness (HAI) at Mt. Kilimanjaro. Tadalafil group had lower rates of severe HAI compared with controls (4% vs 26%, p = 0.03), mostly because of decreased high-altitude pulmonary edema rates (4% vs 22%, p = 0.06). © 2012 International Society of Travel Medicine.
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Leshem, E., Caine, Y., Rosenberg, E., Maaravi, Y., Hermesh, H., & Schwartz, E. (2012). Tadalafil and acetazolamide versus acetazolamide for the prevention of severe high-altitude illness. Journal of Travel Medicine, 19(5), 308–310. https://doi.org/10.1111/j.1708-8305.2012.00636.x