Lysophosphatidic acid (LPA; monoacyl-glycerol-3-phosphate) is a lipid mediator that functions as a mitogen and motility factor for many cell types. LPA signals through six specific G protein-coupled receptors, named LPA 1-6, which trigger both overlapping and distinct signaling pathways. LPA is produced from extracellular lysophosphatidylcholine by a secreted lysophospholipase D, named autotaxin (ATX), originally identified as an "autocrine motility factor" for tumor cells. ATX-LPA signaling is vital for embryonic development and promotes tumor formation, angiogenesis, and experimental metastasis in mice. Elevated expression of ATX and/or aberrant expression of LPA receptors are found in several human malignancies, while loss of LPA 6 function has been implicated in bladder cancer. In this review, we summarize our present understanding of ATX and LPA receptor signaling in cancer. © 2011 Springer Science+Business Media, LLC.
CITATION STYLE
Houben, A. J. S., & Moolenaar, W. H. (2011, December). Autotaxin and LPA receptor signaling in cancer. Cancer and Metastasis Reviews. https://doi.org/10.1007/s10555-011-9319-7
Mendeley helps you to discover research relevant for your work.