Mandibulo-facial dysostosis (treacher collins syndrome)

Abstract

A typical case of the Treacher Collins syndrome (mandibulofacial dysostosis) is described with the clinical features and the abnormal details of its anatomy. A fresh suggestion regarding the cause of the abnormality is put forward, based chiefly on the arterial abnormalities present in this case, viz. that a defect of the stapedial artery causes maldevelopment not only in its own field of supply but also in the region of the first visceral arch whose vessels the stapedial artery normally supports during the critical phase between the disappearance of the first aortic arch and the full development of the external carotid artery, just after the formation of the primitive face. The normal development of the arteries in and near the first visceral arch is reconsidered and modified.