Histone deacetylase sirtuin 1 deacetylates IRF1 protein and programs dendritic cells to control Th17 protein differentiation during autoimmune inflammation

Abstract

Background: The roles of Sirt1 in regulating dendritic functions are not known. Results: Sirt1 deacetylates the IRF1 transcription factor to suppress IL-27 expression in dendritic cells, leading to elevated Th17 differentiation for inflammatory disease development. Conclusion: Sirt1 programs DC functions to promote Th17 differentiation and inflammation. Significance: This study defines a previously unappreciated inflammatory role of Sirt1 in dendritic cells. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.