Medical oncology management of hereditary colorectal cancer

Abstract

Hereditary colorectal cancer syndromes represent approximately 5% of the total of colorectal cancer cases. Although there are a myriad of diseases that are considered rare due to their frequency, there are two conditions that are common enough to be found in the daily medical oncology clinic: Lynch syndrome and Familial Adenomatous Polyposis. In this chapter, we will review the specific aspects of these two conditions from the medical oncology standpoint with particular emphasis to the use of systemic chemotherapy and targeted therapies for the treatment of these cases.