Representative tumor samples and mucosal samples were taken from three different groups of patients and were stained immunohistochemically for their expressions of epidermal growth factor receptors (EGFR). Patients in group 1 had oral squamous carcinoma, with specimens taken from the tumor as well as from the mucosa without tumor invasion. Patients in group 2 had no evidence of tumor but had heavy drinking and smoking habits. Tumor-free patients who do not drink or smoke served as the control group. The findings in the present study showed that the tumor and mucosal samples from groups 1 and 2 had increased EGFR expression while the control group showed significantly less EGFR. These results suggest that EGFR may play a role in the development of premalignant tissue changes, which are probably influenced by chronic toxic irritation. © 1989 Springer-Verlag.
CITATION STYLE
Bergler, W., Bier, H., & Ganzer, U. (1989). The expression of epidermal growth factor receptors in the oral mucosa of patients with oral cancer. Archives of Oto-Rhino-Laryngology, 246(3), 121–125. https://doi.org/10.1007/BF00456651
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