Role of the porous structure of the bioceramic scaffolds in bone tissue engineering

Abstract

The porous structure of biomaterials plays a critical role in improving the efficiency of biomaterials in tissue engineering. Here we fabricate successfully porous bioceramics with accurately controlled pore parameters, and investigate the effect of pore parameters on the mechanical property, the cell seeding proliferation and the vascularization of the scaffolds. This study shows that the porosity play an important role on the mechanical property of the scaffolds, which is affected not only by the macropores size, but also by the interconnections of the scaffolds. Larger pores are beneficial for cell growth in scaffolds. In contrast, the interconnections do not affect cell growth much. The interconnections appear to limit the number of blood vessels penatrating through adjacent pores, and both the pores size and interconnections can determine the size of blood vessels. The results may be referenced on the selective design of porous structure of biomaterials to meet the specificity of biological application.