Exploiting Epigenetic Alterations in Prostate Cancer

4Citations
Citations of this article
59Readers
Mendeley users who have this article in their library.

Abstract

Prostate cancer affects an increasing number of men worldwide and is a leading cause of cancer-associated deaths. Beside genetic mutations, many epigenetic alterations including DNA and histone modifications have been identified in clinical prostate tumor samples. They have been linked to aberrant activity of enzymes and reader proteins involved in these epigenetic processes, leading to the search for dedicated inhibitory compounds. In the wake of encouraging anti-tumor efficacy results in preclinical models, epigenetic modulators addressing different targets are now being tested in prostate cancer patients. In addition, the assessment of microRNAs as stratification biomarkers, and early clinical trials evaluating suppressor microRNAs as potential prostate cancer treatment are being discussed.

Cite

CITATION STYLE

APA

Baumgart, S. J., & Haendler, B. (2017, May 9). Exploiting Epigenetic Alterations in Prostate Cancer. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms18051017

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free