Mitochondrially mediated integrin αiIbβ3 protein inactivation limits thrombus growth

Abstract

Background: Changes in integrin αIIbβ3 binding affinity occur in strongly stimulated platelets. Results: Platelet mitochondrial permeability transition pore formation enhances calpain activity, which leads to integrin β3-associated proteolytic cleavage and integrin inactivation. Conclusion: Mitochondrially mediated integrin αIIbβ3 inactivation limits platelet aggregation and thrombus growth. Significance: Modulation of this pathway may offer a novel alternative for the prevention of thrombosis. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.