Meta-analysis of human IgG anti-HEV seroprevalence in industrialized countries and a review of literature

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Abstract

Although Hepatitis E is increasingly described as a major cause of liver disease in industrialized countries, the epidemiology is far from being fully elucidated. We provide here a comprehensive review of documented clusters of cases, and of serological studies conducted in populations with distinct types of exposure. Seroprevalence rates range from <5% to >50% depending on the countries and the groups of population. Such discrepancies can be attributed to the type of serological assay used, but this solves only a part of the problem. We performed a meta-analysis of studies performed with the broadly used Wantai HEV-IgG ELISA and found striking differences that remain difficult to understand with the current knowledge of transmission pathways.

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Capai, L., Falchi, A., & Charrel, R. (2019, January 1). Meta-analysis of human IgG anti-HEV seroprevalence in industrialized countries and a review of literature. Viruses. MDPI AG. https://doi.org/10.3390/v11010084

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