Hyperhomocysteinemia and risk of cervical cancer

Abstract

Homocysteine (HCys) is a major metabolite that involved in the biosynthesis and metabolism of methionine (Met), and plays a fundamental role in the physiological cell's life cycle. Hyperhomocysteinemia (HHCys) is acknowledged as a risk factor for numerous diseases, including cardiovascular (CVD), diabetes, neurological conditions and cancers. The high concentration of Hcys to be caused mainly by the widely diffused polymorphisms of several enzymes. Currently, a blood test can easily detect HCys elevated concentrations, mentioned to as Hyperhomocysteinemia (HHCys). Persistent acquaintance to this situation can lead to the onset of cardiovascular disease (CVD) and can also lead to the development of stroke, atherosclerosis, inflammatory syndromes like osteoporosis and rheumatism, as well as neuronal pathologies including Alzheimer's (AD) and Parkinson's diseases (PD). In this chapter, we review biosynthesis, metabolism and conditions that induce high homocysteine levels in blood, and associated diseases related to elevated levels of homocysteine, especially cervical cancer.