Decreased Level of Neuropeptide Y Is Associated With Gastroparesis in Male Diabetic Rats

Abstract

Background: Substance P (SP) and neuropeptide Y (NPY), excitato-ry and inhibitory neuropeptides, respectively, may impact gastric mo-tility in patients with diabetic mellitus (DM). We investigated these neuropeptide levels, NPY receptors, total nitric oxide synthase (NOS) levels, and neuronal NOS alpha (nNOSα) activation status and levels in streptozotocin-induced type I diabetes in male rats.