ATN-10, Mn-metalloporphyrin, has been developed as a tumor selective contrast agent for magnetic resonance (MR) imaging. To investigate the tumor specificity of ATN-10, we produced three experimental in vivo models; rat bran tumor (9L glioma) model. vasogenic (cold injury) and cytotoxic brain edema (24-hour MCA occlusion) models. The time course of contrast enhancement was compared after intravenous injection of ATN-10 or Gd-DTPA, measuring the signal intensity of the region of interest. After ATN-10 administration, the 9L glioma model showed early (5 min) and delayed (24 hr-) peak enhancement whereas the cold injury model showed only early enhancement and the 24-hour MCA occlusion model did not show significant enhancement. After Gd-DTPA administration, all three models showed similar pattern of only early enhancement. As a contrast agent for MR imaging, ATN-10 showed different behavior than Gd-DTPA in demonstrating the blood-brain barrier disruption and moreover ATN-10 showed selective enhancement in experimental brain tumors.
CITATION STYLE
Fujimori, H., Matsumura, A., Yamamoto, T., Shibata, Y., Yoshizawa, T., Nakagawa, K., … Nakajima, S. (1997). Tumor Specific Contrast Enhancement Study of Mn-Metalloporphyrin (ATN-10) - Comparison of Rat Brain Tumor Model, Cytotoxic and Vasogenic Edema Models. Acta Neurochirurgica, Supplement, 1997(70), 167–169. https://doi.org/10.1007/978-3-7091-6837-0_51
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