Poly(amino ester)s-Based Polymeric Gene Carriers in Cancer Gene Therapy

Abstract

Hyperbranched poly(amido amine) (PAMAM) was prepared by Michael addition reaction of methyl acrylate (MA) and ethidenediamine (EDA). The result showed that fluorescence intensities increased with increasing the molecular weight. Importantly, the present work showed a new kind of fluorescence-emitting moieties in the fluorescence spectra, which different from the results as reported in PAMAM dendrimers.