Contamination of anaesthetic gases with nitric oxide and its influence on oxygenation: Study in patients undergoing open heart surgery

Abstract

Background. Nitric oxide is important in vasomotor regulation. Contamination of anaesthetic gases with nitric oxide could affect gas exchange. Methods. We measured oxygenation and nitric oxide concentrations in the inspiratory and expiratory limb of the ventilator circuit in patients about to have cardiac surgery. Measurements were made before surgery when the circulation and respiratory conditions were stable. F1O2, was set at 0.35. The breathing circuit was supplied with a fresh gas flow greater than the minute volume so that exhaled gas was not re-used. Three gas mixtures were given in sequence to each patient: oxygen and compressed air (AIRc), oxygen and nitrous oxide, and oxygen and synthetic air (AIRs) that was free from nitric oxide. All patients were given AIRs as the second gas and the other two gas mixtures (AIRc and nitrous oxide) were given randomly as the first and third gases. Results. During ventilation with oxygen-AIRc, the median nitric oxide concentration was 5.6 ppb, during ventilation with oxygen-nitrous oxide it was 5.0 ppb and using oxygen-AIRs it was 1.5 ppb. When AIRc and nitrous oxide were used, PaO2, was greater and venous admixture was less than when AIRs was used. The different gas mixtures did not affect pulmonary vascular pressures or cardiac ouput. Conclusions. Compressed air and nitrous oxide contain very low concentrations of nitric oxide (<10 ppb). This can affect pulmonary oxygen transfer during anaesthesia. © The Board of Management and Trustees of the British Journal of Anaesthesia 2004.