Chemical and biological investigation of Araucaria heterophylla salisb. Resin

Abstract

Three labdane diterpenes, namely labda-8(17),14-diene, 13-epicupressic acid, and 13-O- acetyl-13-epicupressic acid, were isolated from the resin collected from stem exudates of Araucaria heterophylla Salisb. (Araucariaceae). The isolated compounds were identified using different spectroscopic methods (1H NMR, 13C NMR, HMQC, HMBC and COSY). The resin extract showed antiulcerogenic activity against ethanol-induced stomach ulcers in Sprauge Dawely rats using ranitidine as standard. In addition, the resin and the isolated compounds showed variable cytotoxic activities against breast (MCF7) and colon (HCT116) cancer cell lines. © 2009 Verlag der Zeitschrift für Naturforschung, Tübingen.