Reproducible evaluation of registration algorithms for movement correction in dynamic contrast enhancing magnetic resonance imaging for breast cancer diagnosis

Abstract

Accurate methods for computer aided diagnosis of breast cancer increase accuracy of detection and provide support to physicians in detecting challenging cases. In dynamic contrast enhancing magnetic resonance imaging (DCE-MRI), motion artifacts can appear as a result of patient displacements. Non-linear deformation algorithms for breast image registration provide with a solution to the correspondence problem in contrast with affine models. In this study we evaluate 3 popular non-linear registration algorithms: MIRTK, Demons, SyN Ants, and compare to the affine baseline. We propose automatic measures for reproducible evaluation on the DCE-MRI breast-diagnosis TCIA-database, based on edge detection and clustering algorithms, and provide a rank of the methods according to these measures.