Abstract
Cytotoxic immunosuppressive agents have a long-standing important role in pharmacological IMMUNOSUPPRESSION. Azathioprine was among the first immunosuppressive drugs used in organ transplantation. A further development in this field was landmarked by the introduction of ALKYLATING AGENTS (i.e. cyclophosphamide) and ANTIMETABOLITES (i.e. methotrexate and mycophenolic acid) in therapeutic regimens for the prevention of graft rejection (see Chap. 31) and the treatment of AUTOIMMUNE DISEASES (see Chaps. 34 and 35) because of their well-documented lymphocytolytic effect.
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CITATION STYLE
Grösch, S., Bocci, G., Paolo, A. D., & Danesi, R. (2019). Cytotoxic Drugs. In Nijkamp and Parnham’s Principles of Immunopharmacology: Fourth revised and extended edition (pp. 613–627). Springer International Publishing. https://doi.org/10.1007/978-3-030-10811-3_30
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